Antidotes to coumarins, isoniazid, methotrexate and thyroxine, toxins that work via metabolic processes

Title: Antidotes to coumarins, isoniazid, methotrexate and thyroxine, toxins that work via metabolic processes
Creator: Bateman, D. Nicholas; Page, Colin B.
Relation: British Journal of Clinical Pharmacology Vol. 81, Issue 3, p. 437-445
Publisher Link: http://dx.doi.org/10.1111/bcp.12736
Publisher: Wiley-Blackwell
Resource Type: journal article
Date: 2015
Description: Some toxins cause their effects by affecting physiological processes that are fundamental to cell function or cause systemic effects as a result of cellular interaction. This review focuses on four examples, coumarin anticoagulants, isoniazid, methotrexate and thyroxine from the context of management of overdose as seen in acute general hospitals. The current basic clinical pharmacology of the toxin, the clinical features in overdose and evidence base for specific antidotes are discussed. The treatment for this group is based on an understanding of the toxic mechanism, but studies to determine the optimum dose of antidote are still required in all these toxins except thyroxine, where treatment dose is based on symptoms resulting from the overdose.
Subject: antidotes; coumarin anticoagulant; isoniazid; methotrexate; poisoning; thyroxine
Identifier: http://hdl.handle.net/1959.13/1317208
Identifier: uon:23362
Identifier: ISSN:0306-5251
Language: eng
Reviewed

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